Real-Time Continuous Glucose Monitoring in a Newborn with Congenital Hyperinsulinism

Date of submission: 19-03-2020 | Date of acceptance: 18-05-2020 | Published: 02-10-2020

Abstract

Congenital hyperinsulinism, also known as persistent hyperinsulinemic hypoglycemia of infancy, is the most frequent cause of severe, recurrent and persistent hypoglycemia in children. The signs and symptoms of hypoglycemia are particularly difficult to recognize in this age group, which can lead to serious neurological impairment or even death. 

Continuous glucose monitoring provides real-time information about interstitial fluid glucose levels throughout the day and has proven to be useful in preventing hypoglycemia. Despite this, there are only a few studies in the literature describing the use of continuous glucose monitoring systems in neonatal hypoglycemia, particularly in children with congenital hyperinsulinism.

In this case report, the authors present their experience with real-time continuous glucose monitoring system in a neonate with congenital hyperinsulinism, associated with a novel missense variant in ABCC8 gene.